Antiprotease deficiency and rare form of cancer: A case report

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An increased incidence of deficiency of serum antiproteases has been reported in patients with chronic obstructive pulmonary disease but has not been well proven in association with other conditions. Currently taking place around the world debate on the role of serpin (serine protease inhibitor) in tumor genesis. Protease inhibitors such as alpha-1 antitrypsin were kept counteract tumor progression and metastasis, because of their ability to inhibit proteases. So is there any connection between inherited alpha-1 antitrypsin deficiency and Chondrosarcoma? Here is reported 47-year-old woman, that was admitted to the Oncology Department because of humerus Chondrosarcoma signs . The patient also had a history of chronic obstructive pulmonary disease. After a chest X-ray and consulting pulmonologist alpha-1 antitrypsin deficiency was suspected. Severe Alpha-1 antitrypsin deficiency (PIZZ homozygous genotype) was established. Alpha 1-antitrypsin deficiency may have facilitated the development of Chondrosarcoma. Due to the low incidence of such diseases, we assume that there is little chance of such rare disorders goes together in the same patient.
Original languageEnglish
Pages (from-to)1373-1377
JournalInternational journal of advances in case reports
Issue number23
Publication statusPublished - 2015



  • Protease
  • Cancer
  • Health

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