Chloride/bicarbonate exchanger in rat thymic lymphocytes: Experimental investigation and mathematical modeling

Donatas Stakišaitis, Z. Driziene, S. Uleckiene, B. Kazbariene, J. Didziapetriene

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Aim and methods. Hypomagnesemia is a frequent adverse effect of chemotherapy in cancer patients. Its gender-dependent peculiarities are unknown. The aim of the current work was to define peculiarities of urinary magnesium (Mg) excretion in healthy adolescents; to elucidate gender-related differences in Mg urinary excretion; to determine a correlation between urinary Mg excretion and arterial blood pressure (BP) in healthy adolescents. Mg was examined in diurnal and nocturnal urine of adolescent boys (n = 27) and girls (n = 42) aged 13 - 17 years. Urinary Mg (both during day and night) was monitored 24-h concomitantly with BP (hourly) in 44 adolescents (22 girls and 22 boys). Additionally, of the same girls 15 were examined during different phases of their menstrual cycle (follicular, ovulation and luteal). Results. 24-h urinary Mg excretion was significantly higher in boys than in girls (2.66 +/- 0.9 mmol vs. 2.1 +/- 0.9 mmol; p < 0.05). Nocturnal systolic BP was significantl y higher (p < 0.05) in boys than in girls in all phases of their menstrual cycle. Diurnal systolic BP in boys was significantly higher than in girls during the follicular phase. It revealed a significant positive correlation between Mg excretion and BP in boys at night (p < 0.05). Girls exhibited a significant inverse correlation between Mg nocturnal excretion and BP (p < 0.05) during the luteal phase of their menstrual cycle, as well as a significant negative correlation between diurnal Mg excretion and BP (p < 0.05) during the ovulation phase. Urine Mg was negatively related to height in girls (p < 0.05). Conclusion. Mg urinary excretion is related to gender, height, circadian rhythm, and blood pressure. The further preclinical and clinical studies of gender-related risks of hypomagnesemia under chemotherapeutic treatment could contribute to improving the efficacy of anticancer treatment.
    Original languageEnglish
    Pages (from-to)208-212
    JournalTrace Elements and Electrolytes
    Volume28
    Issue number4
    DOIs
    Publication statusPublished - 2011

    Fingerprint

    Chloride-Bicarbonate Antiporters
    Lymphocytes
    Magnesium
    Rats
    Blood pressure
    Blood Pressure
    Follicular Phase
    Luteal Phase
    Ovulation
    Urine
    Chemotherapy
    Menstrual Cycle
    Circadian Rhythm
    Arterial Pressure

    Keywords

    • Magnesium
    • Gender
    • Cisplatin
    • Women
    • Children
    • Calcium
    • Age

    Cite this

    Chloride/bicarbonate exchanger in rat thymic lymphocytes : Experimental investigation and mathematical modeling. / Stakišaitis, Donatas ; Driziene, Z.; Uleckiene, S.; Kazbariene, B.; Didziapetriene, J.

    In: Trace Elements and Electrolytes, Vol. 28, No. 4, 2011, p. 208-212.

    Research output: Contribution to journalArticle

    Stakišaitis, Donatas ; Driziene, Z. ; Uleckiene, S. ; Kazbariene, B. ; Didziapetriene, J. / Chloride/bicarbonate exchanger in rat thymic lymphocytes : Experimental investigation and mathematical modeling. In: Trace Elements and Electrolytes. 2011 ; Vol. 28, No. 4. pp. 208-212.
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    abstract = "Aim and methods. Hypomagnesemia is a frequent adverse effect of chemotherapy in cancer patients. Its gender-dependent peculiarities are unknown. The aim of the current work was to define peculiarities of urinary magnesium (Mg) excretion in healthy adolescents; to elucidate gender-related differences in Mg urinary excretion; to determine a correlation between urinary Mg excretion and arterial blood pressure (BP) in healthy adolescents. Mg was examined in diurnal and nocturnal urine of adolescent boys (n = 27) and girls (n = 42) aged 13 - 17 years. Urinary Mg (both during day and night) was monitored 24-h concomitantly with BP (hourly) in 44 adolescents (22 girls and 22 boys). Additionally, of the same girls 15 were examined during different phases of their menstrual cycle (follicular, ovulation and luteal). Results. 24-h urinary Mg excretion was significantly higher in boys than in girls (2.66 +/- 0.9 mmol vs. 2.1 +/- 0.9 mmol; p < 0.05). Nocturnal systolic BP was significantl y higher (p < 0.05) in boys than in girls in all phases of their menstrual cycle. Diurnal systolic BP in boys was significantly higher than in girls during the follicular phase. It revealed a significant positive correlation between Mg excretion and BP in boys at night (p < 0.05). Girls exhibited a significant inverse correlation between Mg nocturnal excretion and BP (p < 0.05) during the luteal phase of their menstrual cycle, as well as a significant negative correlation between diurnal Mg excretion and BP (p < 0.05) during the ovulation phase. Urine Mg was negatively related to height in girls (p < 0.05). Conclusion. Mg urinary excretion is related to gender, height, circadian rhythm, and blood pressure. The further preclinical and clinical studies of gender-related risks of hypomagnesemia under chemotherapeutic treatment could contribute to improving the efficacy of anticancer treatment.",
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    author = "Donatas Stakišaitis and Z. Driziene and S. Uleckiene and B. Kazbariene and J. Didziapetriene",
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    T1 - Chloride/bicarbonate exchanger in rat thymic lymphocytes

    T2 - Experimental investigation and mathematical modeling

    AU - Stakišaitis, Donatas

    AU - Driziene, Z.

    AU - Uleckiene, S.

    AU - Kazbariene, B.

    AU - Didziapetriene, J.

    PY - 2011

    Y1 - 2011

    N2 - Aim and methods. Hypomagnesemia is a frequent adverse effect of chemotherapy in cancer patients. Its gender-dependent peculiarities are unknown. The aim of the current work was to define peculiarities of urinary magnesium (Mg) excretion in healthy adolescents; to elucidate gender-related differences in Mg urinary excretion; to determine a correlation between urinary Mg excretion and arterial blood pressure (BP) in healthy adolescents. Mg was examined in diurnal and nocturnal urine of adolescent boys (n = 27) and girls (n = 42) aged 13 - 17 years. Urinary Mg (both during day and night) was monitored 24-h concomitantly with BP (hourly) in 44 adolescents (22 girls and 22 boys). Additionally, of the same girls 15 were examined during different phases of their menstrual cycle (follicular, ovulation and luteal). Results. 24-h urinary Mg excretion was significantly higher in boys than in girls (2.66 +/- 0.9 mmol vs. 2.1 +/- 0.9 mmol; p < 0.05). Nocturnal systolic BP was significantl y higher (p < 0.05) in boys than in girls in all phases of their menstrual cycle. Diurnal systolic BP in boys was significantly higher than in girls during the follicular phase. It revealed a significant positive correlation between Mg excretion and BP in boys at night (p < 0.05). Girls exhibited a significant inverse correlation between Mg nocturnal excretion and BP (p < 0.05) during the luteal phase of their menstrual cycle, as well as a significant negative correlation between diurnal Mg excretion and BP (p < 0.05) during the ovulation phase. Urine Mg was negatively related to height in girls (p < 0.05). Conclusion. Mg urinary excretion is related to gender, height, circadian rhythm, and blood pressure. The further preclinical and clinical studies of gender-related risks of hypomagnesemia under chemotherapeutic treatment could contribute to improving the efficacy of anticancer treatment.

    AB - Aim and methods. Hypomagnesemia is a frequent adverse effect of chemotherapy in cancer patients. Its gender-dependent peculiarities are unknown. The aim of the current work was to define peculiarities of urinary magnesium (Mg) excretion in healthy adolescents; to elucidate gender-related differences in Mg urinary excretion; to determine a correlation between urinary Mg excretion and arterial blood pressure (BP) in healthy adolescents. Mg was examined in diurnal and nocturnal urine of adolescent boys (n = 27) and girls (n = 42) aged 13 - 17 years. Urinary Mg (both during day and night) was monitored 24-h concomitantly with BP (hourly) in 44 adolescents (22 girls and 22 boys). Additionally, of the same girls 15 were examined during different phases of their menstrual cycle (follicular, ovulation and luteal). Results. 24-h urinary Mg excretion was significantly higher in boys than in girls (2.66 +/- 0.9 mmol vs. 2.1 +/- 0.9 mmol; p < 0.05). Nocturnal systolic BP was significantl y higher (p < 0.05) in boys than in girls in all phases of their menstrual cycle. Diurnal systolic BP in boys was significantly higher than in girls during the follicular phase. It revealed a significant positive correlation between Mg excretion and BP in boys at night (p < 0.05). Girls exhibited a significant inverse correlation between Mg nocturnal excretion and BP (p < 0.05) during the luteal phase of their menstrual cycle, as well as a significant negative correlation between diurnal Mg excretion and BP (p < 0.05) during the ovulation phase. Urine Mg was negatively related to height in girls (p < 0.05). Conclusion. Mg urinary excretion is related to gender, height, circadian rhythm, and blood pressure. The further preclinical and clinical studies of gender-related risks of hypomagnesemia under chemotherapeutic treatment could contribute to improving the efficacy of anticancer treatment.

    KW - Magnesium

    KW - Gender

    KW - Cisplatin

    KW - Women

    KW - Children

    KW - Calcium

    KW - Age

    U2 - 10.5414/TEX01180

    DO - 10.5414/TEX01180

    M3 - Article

    VL - 28

    SP - 208

    EP - 212

    JO - Trace Elements in Medicine

    JF - Trace Elements in Medicine

    SN - 0946-2104

    IS - 4

    ER -