Gender-related differences in urinary excretion of magnesium in adolescents receiving valproate

Jurgita Grikinienė, Donatas Stakišaitis, Rimas Jankūnas, Birutė Obelenienė

    Research output: Contribution to journalArticle

    Abstract

    Background: Valproates (VPA) are known to increase diuresis and urinary excretion of sodium and chloride in both genders of rats. Magnesiuretic effect of VPA was investigated in rats. Several tests have shown gender-related differences in ion transport across cell membrane and their urinary excretion. Aim of the study: To find peculiarities of urinary magnesium (Mg(2+)) excretion in epileptic adolescents receiving VPA and to elucidate gender-related differences. Materials and methods: We monitored 24-h urinary levels of Mg(2+) and creatinine as well pH in 47 epileptic adolescents receiving VPA and 95 controls. Results: Diurnal, nocturnal and 24-h urinary Mg(2+) excretion in VPA-treated epileptic girls was significantly higher than in controls. Nocturnal diuresis in VPA-treated epileptic girls was significantly higher than in controls. Such differences were not found in epileptic boys receiving VPA. Conclusion: VPA may precipitate disturbance of Mg(2+) homeostasis. VPA-induce!
    Original languageEnglish
    Pages (from-to)48-53
    JournalTrace Elements and Electrolytes
    Volume29
    Issue number1
    DOIs
    Publication statusPublished - 2012

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    Diuresis
    Valproic Acid
    Magnesium
    Rats
    Ion Transport
    Sodium Chloride
    Creatinine
    Homeostasis
    Cell Membrane
    Cell membranes
    Precipitates
    Ions

    Keywords

    • Valproate
    • Magnesium
    • Urine
    • Adolescents
    • Epilepsy
    • Gender

    Cite this

    Gender-related differences in urinary excretion of magnesium in adolescents receiving valproate. / Grikinienė, Jurgita; Stakišaitis, Donatas ; Jankūnas, Rimas; Obelenienė, Birutė.

    In: Trace Elements and Electrolytes, Vol. 29, No. 1, 2012, p. 48-53.

    Research output: Contribution to journalArticle

    Grikinienė, Jurgita ; Stakišaitis, Donatas ; Jankūnas, Rimas ; Obelenienė, Birutė. / Gender-related differences in urinary excretion of magnesium in adolescents receiving valproate. In: Trace Elements and Electrolytes. 2012 ; Vol. 29, No. 1. pp. 48-53.
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    AU - Grikinienė, Jurgita

    AU - Stakišaitis, Donatas

    AU - Jankūnas, Rimas

    AU - Obelenienė, Birutė

    PY - 2012

    Y1 - 2012

    N2 - Background: Valproates (VPA) are known to increase diuresis and urinary excretion of sodium and chloride in both genders of rats. Magnesiuretic effect of VPA was investigated in rats. Several tests have shown gender-related differences in ion transport across cell membrane and their urinary excretion. Aim of the study: To find peculiarities of urinary magnesium (Mg(2+)) excretion in epileptic adolescents receiving VPA and to elucidate gender-related differences. Materials and methods: We monitored 24-h urinary levels of Mg(2+) and creatinine as well pH in 47 epileptic adolescents receiving VPA and 95 controls. Results: Diurnal, nocturnal and 24-h urinary Mg(2+) excretion in VPA-treated epileptic girls was significantly higher than in controls. Nocturnal diuresis in VPA-treated epileptic girls was significantly higher than in controls. Such differences were not found in epileptic boys receiving VPA. Conclusion: VPA may precipitate disturbance of Mg(2+) homeostasis. VPA-induce!

    AB - Background: Valproates (VPA) are known to increase diuresis and urinary excretion of sodium and chloride in both genders of rats. Magnesiuretic effect of VPA was investigated in rats. Several tests have shown gender-related differences in ion transport across cell membrane and their urinary excretion. Aim of the study: To find peculiarities of urinary magnesium (Mg(2+)) excretion in epileptic adolescents receiving VPA and to elucidate gender-related differences. Materials and methods: We monitored 24-h urinary levels of Mg(2+) and creatinine as well pH in 47 epileptic adolescents receiving VPA and 95 controls. Results: Diurnal, nocturnal and 24-h urinary Mg(2+) excretion in VPA-treated epileptic girls was significantly higher than in controls. Nocturnal diuresis in VPA-treated epileptic girls was significantly higher than in controls. Such differences were not found in epileptic boys receiving VPA. Conclusion: VPA may precipitate disturbance of Mg(2+) homeostasis. VPA-induce!

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    KW - Gender

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