Results of prenatal tests in cases after assisted reproductive technologies

Research output: Contribution to journalArticle

Abstract

In vitro fertilisation (IVF) and other assisted reproductive technologies (ART) are effective treatments for infertility and are widely provided in developed countries. However recent scientific publications suggest that there is an elevated risk of major structural malformations, imprinting defects and such syndromes as Prader-Willy, Angelman, Wiedeman-Beckwith. The aim of the study was to analyse if ART are associated with increased risk of genotoxicy for chromosomal nondisjunction in meiosis. Study included analysis of 50 families that prenatally were diagnosed chromosomal anomalies (Down, Turner, Klinefelter, Edwards, Patau syndrome). And control group included 70 families with healthy children. The results of present study showed, that in chromosomal anomalies group three cases of children with chromosomal anomalies were conceived after ART. In control group all healthy children were conceived naturally (p<0.05). The study also showed a statistically significant relationship between: older age of the woman (> 35 years old) and the occurrence of trisomy (p<0.05). The number of observed pathological cases is not so big to make exact conclusions, but results of present study supports hypothesis, that ART are associated with greater risk of chromosomal anomalies in conceived children.
Original languageEnglish
Pages (from-to)991-994
JournalInternational journal of advances in case reports
Volume2
Issue number15
Publication statusPublished - 2015

Fingerprint

Assisted Reproductive Techniques
Control Groups
Trisomy
Meiosis
Fertilization in Vitro
Developed Countries
Infertility
Publications
Therapeutics

Keywords

  • In vitro fertilization
  • Chromosomal anomalies
  • Prenatal diagnostics

Cite this

@article{afbe0a916d6144dca2076ded07060249,
title = "Results of prenatal tests in cases after assisted reproductive technologies",
abstract = "In vitro fertilisation (IVF) and other assisted reproductive technologies (ART) are effective treatments for infertility and are widely provided in developed countries. However recent scientific publications suggest that there is an elevated risk of major structural malformations, imprinting defects and such syndromes as Prader-Willy, Angelman, Wiedeman-Beckwith. The aim of the study was to analyse if ART are associated with increased risk of genotoxicy for chromosomal nondisjunction in meiosis. Study included analysis of 50 families that prenatally were diagnosed chromosomal anomalies (Down, Turner, Klinefelter, Edwards, Patau syndrome). And control group included 70 families with healthy children. The results of present study showed, that in chromosomal anomalies group three cases of children with chromosomal anomalies were conceived after ART. In control group all healthy children were conceived naturally (p<0.05). The study also showed a statistically significant relationship between: older age of the woman (> 35 years old) and the occurrence of trisomy (p<0.05). The number of observed pathological cases is not so big to make exact conclusions, but results of present study supports hypothesis, that ART are associated with greater risk of chromosomal anomalies in conceived children.",
keywords = "In vitro fertilization, Chromosomal anomalies, Prenatal diagnostics",
author = "Danielius Serapinas",
year = "2015",
language = "English",
volume = "2",
pages = "991--994",
journal = "International journal of advances in case reports",
issn = "2349-8005",
number = "15",

}

TY - JOUR

T1 - Results of prenatal tests in cases after assisted reproductive technologies

AU - Serapinas, Danielius

PY - 2015

Y1 - 2015

N2 - In vitro fertilisation (IVF) and other assisted reproductive technologies (ART) are effective treatments for infertility and are widely provided in developed countries. However recent scientific publications suggest that there is an elevated risk of major structural malformations, imprinting defects and such syndromes as Prader-Willy, Angelman, Wiedeman-Beckwith. The aim of the study was to analyse if ART are associated with increased risk of genotoxicy for chromosomal nondisjunction in meiosis. Study included analysis of 50 families that prenatally were diagnosed chromosomal anomalies (Down, Turner, Klinefelter, Edwards, Patau syndrome). And control group included 70 families with healthy children. The results of present study showed, that in chromosomal anomalies group three cases of children with chromosomal anomalies were conceived after ART. In control group all healthy children were conceived naturally (p<0.05). The study also showed a statistically significant relationship between: older age of the woman (> 35 years old) and the occurrence of trisomy (p<0.05). The number of observed pathological cases is not so big to make exact conclusions, but results of present study supports hypothesis, that ART are associated with greater risk of chromosomal anomalies in conceived children.

AB - In vitro fertilisation (IVF) and other assisted reproductive technologies (ART) are effective treatments for infertility and are widely provided in developed countries. However recent scientific publications suggest that there is an elevated risk of major structural malformations, imprinting defects and such syndromes as Prader-Willy, Angelman, Wiedeman-Beckwith. The aim of the study was to analyse if ART are associated with increased risk of genotoxicy for chromosomal nondisjunction in meiosis. Study included analysis of 50 families that prenatally were diagnosed chromosomal anomalies (Down, Turner, Klinefelter, Edwards, Patau syndrome). And control group included 70 families with healthy children. The results of present study showed, that in chromosomal anomalies group three cases of children with chromosomal anomalies were conceived after ART. In control group all healthy children were conceived naturally (p<0.05). The study also showed a statistically significant relationship between: older age of the woman (> 35 years old) and the occurrence of trisomy (p<0.05). The number of observed pathological cases is not so big to make exact conclusions, but results of present study supports hypothesis, that ART are associated with greater risk of chromosomal anomalies in conceived children.

KW - In vitro fertilization

KW - Chromosomal anomalies

KW - Prenatal diagnostics

M3 - Article

VL - 2

SP - 991

EP - 994

JO - International journal of advances in case reports

JF - International journal of advances in case reports

SN - 2349-8005

IS - 15

ER -